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Alveolar–arterial gradient
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Alveolar–arterial gradient : ウィキペディア英語版
Alveolar–arterial gradient

The Alveolar–arterial gradient (A-aO2,〔 or A–a gradient), is a measure of the difference between the alveolar concentration (A) of oxygen and the arterial (a) concentration of oxygen. It is used in diagnosing the source of hypoxemia.〔(【引用サイトリンク】title=iROCKET Learning Module: Intro to Arterial Blood Gases, Pt. 1 )
It helps to assess the integrity of alveolar capillary unit. For example, in high altitude, the arterial oxygen PaO2 is low but only because the alveolar oxygen (PAO2) is also low. However, in states of ventilation perfusion mismatch, such as pulmonary embolism or right-to-left shunt, oxygen is not effectively transferred from the alveoli to the blood which results in elevated A-a gradient
== Equation ==
The equation for calculating the A–a gradient is:
:Aa~Gradient=P_AO_2-P_aO_2〔(【引用サイトリンク】title=Alveolar-arterial Gradient )
Where:
* PAO2 = alveolar PO2 (calculated from the alveolar gas equation)
::P_AO_2=F_iO_2(P_-P_)-\frac
* PaO2 = arterial PO2 (measured in arterial blood)
In its expanded form, the A–a gradient can be calculated by:
:Aa~Gradient=\left(F_iO_2(P_-P_)-\frac\right)-P_aO_2
On room air ( FiO2 = 0.21, or 21% ), at sea level ( Patm = 760 mmHg ) assuming 100% humidity in the alveoli, a simplified version of the equation is:
:Aa~Gradient=\left(150-\frac(P_)\right)-P_aO_2

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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